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Academic Degrees

  • Bachelor in Physiology & Cell Biology, University of Rennes I (France) – 1988.
  • Master in Molecular & Cell Biology, University Blaise Pascal, Clermont-Ferrand (France) – 1990.
  • Ph.D. in Molecular & Cell Biology (Immunology), College of Agriculture of Rennes (France) – 1994.

 

Research

  • The Research projects ongoing in Dr. Dréau’s laboratory focus on understanding the molecular, cellular, and physiological bases of metastases associated with cancers of epithelial origin.
  • The cancers of epithelial origin include: the most lethal skin cancer, i.e. melanoma and the most common solid tumor in female i.e., breast cancer. In these cancers as in others, the occurrence of metastases is associated with a high mortality (see the site of the American Cancer Society for details on cancer statistics in the US: http://www.cancer.org)
  • The development of metastases is a multi-step process, which, from the tumor standpoint, includes:
    1. Development of tumor cells with metastatic potentials.
    2. Detachment, migration of tumor cells generally through the vascular system (blood, lymph vessels), and anchoring within the host tissue.
    3. Growth of the metastatic mass requiring the concurrent development of vessels, i.e. neo-angiogenesis, which provide oxygen and various nutriments.
    4. Preventing responses of the immune system throughout all the steps associated with the development of tumor metastases.

Dr. Dréau’s research centers on the mechanisms of cancer metastasis, and the vascular and immune interactions associated with cancer growth. More specifically, the following aspects of cancer metastasis are studied:

  1. Key features of Metastatic Tumors
  2. Anchoring and Growth of Metastatic Tumors
  3. Vascularization of the Metastatic Tumors
  4. Interactions Immune System and Metastases

 

Research Opportunities:

  • Potential Graduate Students (Ph.D. or M.S.) should contact Dr. Didier Dréau at: ddreau@uncc.edu
  • EFRI-REM Fellowships are available for Summer 2014. For a brief description of the Fellowship and the application form, check the following  websites: http://clas-pages.uncc.edu/efri/.

 

Lab Members

  • Michelle Coleman, M.D., Ph.D. student
  • Yas Moghaddam, PhD. Candidate (VCU)
  • Rachel Helms, PhD student
  • Mariah Andrews, UG student

 

Lab  Alumni

 

  • Postdoctoral Fellows

– Muthulekha Swamydas, PhD (2008-2010)

– Danielle Van, PhD (2011-2012)

 

  • Graduate students

– Stephen L. Rego, PhD (2013). “Factors shed by breast tumor cell, tumor necrosis factor alpha converting enzyme activities and the generation of pro-tumor macrophages” UNC Charlotte

– Anindita Das Burman MS (2013). “TGF-β (beta) and periostin modulate each others expressions in both breast stroma and cancer cells” Skovde University, Sweden

– Krista Ricci, MS (2012). “Hypoxia and breast cell migration” UNC Charlotte

– Adam Secret, MS (2010). “Breast cancer cell responses to TGFß are affected by hypoxia and the extracellular matrix” UNC Charlotte

– Ashley Jewell, MS thesis (2010). “Endothelin-1, inflammatory cytokines, and macrophages in breast cancer” UNC Charlotte

– Andrew Cox, MS (2008). “Hypoxia, vascular endothelial growth factor, and endothelin in human breast cancer” UNC Charlotte

 

  • Honors Undergraduate students

– Kerri Ann McDermott (2005-2006)

– Do (Jason) Nguyen (2006-2007)

– Hebah Sadek (2007-2008)

– Alim Hamid (2008-2009)

– Amber Lathom Yow (2009-2010)

– Ashley Brooker (2011-2012)

– Ronald Valencia (2011-2012)

– Alexander de Piante (2012)

– Rachel Helms (2012-2013)

 

 

Selected Publications

Courses Taught

BIOL 4171/5171 Cell Physiology

BIOL 3273 Animal Physiology

BIOL 2000 UG experience EFRi-REM program

BIOL 6000/8000 Special Topics in Cancer Biology: Initiation to Metastasis

BIOL4600 Senior Seminar

BIOL 6273 Adv. Human Physiology

BIOL 6143 Integrated Physiology

 

Professional Experience

  • 1994-1996 Research Fellowship in Infection and Immunology, Carolinas Medical Center, Charlotte.
  • 1996-1997 Research Fellowship in Cancer Immunology, Carolinas Medical Center, Charlotte.
  • 1998-2002 Research scientist Dept General Surgery, Carolinas Medical Center, Charlotte.
  • 2002-2002 Director of Immunology & Oncology Research, Carolinas Medical Center, Charlotte.
  • 2003-2004 Research scientist Department of Biology, University of North Carolina at Charlotte.
  • 2004-2010 Assistant Professor, Department of Biology, University of North Carolina at Charlotte.
  • 2010-Present Associate Professor, Department of Biology, University of North Carolina at Charlotte.

 

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